Suggest another method to measure particle size, if both methods are not suitable to analyze particles size of any samples.Ĭoulter Counter can also be one of the methods to measure particle size.This data is then analyzed to calculate the size of particles that created the scattering pattern. It uses the technique of laser diffraction to measure the size of particles by measuring the intensity of light scattered as a laser beam passing through a dispersed particulate sample. Modular in design, it has a wide range of automated sample dispersion units for the measurement of wet and dry samples. As for the Malvern Mastersizer, this analyzer has set the standard for simple, straight forward operation. Zeta potential in aqueous and non aqueous dispersions can we measured accurately. By using Malvern Zetasizer, measurements of particles and molecules from 0.6nm to 8.9 microns.
By using the technique technology within the Zetasizer system there parameters can be measured over a wide range of concentrations. These three fundamental parameters are Particle size, Zeta potential and Molecular weight. The Zetasizer Nano range of instruments provides the ability to measure three characteristic of particles or molecules in a liquid medium. Discuss the appropriateness of using the above methods to analyse the samples.However, zeta potential which refer to the charge at a distance from the particle is measured instead of measuring surface charge because it cannot be measured directly. It is an important factor in determining the interactions between particles, and hence dispersion characteristics. Thus, the other important parameter is surface properties specifically the surface charge. When there are reducing in the particle size, however, as particle size reduces, the surface area increases significantly in comparison with the volume, so surface properties increasingly determine the dispersions characteristics. Particle size is considered as one of the most important parameters. Describe TWO (2) parameters which should be provided when using Malvern Zetasizer ® and Mastersizer ®.The cell is load and the measurement is run.The Malvern Zetasizer or Mastersizer is power up.Polystyrene nanoparticles from Malvern, U.K ( Sample D) To be able to determine the best method to measure particle size for each product.To be able to analyse and interpret the data obtained.To be able to determine particle size and size distribution of different products using different methods of particle size analysis.To be able to use the instruments to analyse particle size.It is best used to measure nanoparticle size particles. Meanwhile, zetasizer measure particle and molecular size from below a nanometer to several microns, zeta potential, electrophoretic mobility and molecular weight. Particles over a wide size range, from submicron to a few millimetres, are measured accurately and non-destructively, for both wet and dry dispersions. Mastersizer is working by the innovative use of laser diffraction technology. However, the accurate measurements can be obtained by using mastersizer or zetasizer instruments and few others.
There are different methods to analyse the particle size such as sieving, microscope counting, coulter current, dynamic light scattering method, aerosol mass spectrometry and others. The measurement of particle size distributions is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture of many products. TITLE : EXAMINATION OF PHARMACEUTICAL FORMULATIONS USING LASER LIGHT SCATTERING METHODįor a particular sample, the most important physical property is particle size.